Apply IOPE Retinol Expert 0.3% in the evening on clean, dry skin, after your lotion/toner and before your moisturizer. Start with 2 evenings per week to acclimate your skin, then gradually increase if it tolerates well. Use a very small amount, avoiding the eye and lip areas. In the morning, always apply a sunscreen with at least SPF 30, which is essential when using retinol.