Apply a small amount of IOPE Retinol Expert 0.1% in the evening, on clean and completely dry skin, targeting marked areas (forehead wrinkles, around the mouth, crow’s feet…). Start 2 to 3 times a week to get your skin used to it, then gradually increase the frequency if your skin tolerates it well. Always use a good moisturizer afterward and never forget sunscreen during the day, as retinol makes the skin more sensitive to UV rays.