Apply the GENABELLE Glutathione Vita Glow Spicule Shot to clean skin, right after toner. Pump a few pumps over the entire face, then gently massage until absorbed – you may feel slight tingling, which is normal with spicules. Preferably use it in the evening, 2 to 3 times a week at first, then adjust according to your skin’s tolerance. Always finish with a moisturizer, and don’t forget good sun protection in the morning to enhance the glow effect of glutathione and vitamins.