Apply this serum in the evening on clean, dry skin, after your lotion/toner. Dispense 1 to 2 pumps over the entire face, avoiding the eye and mouth areas, then gently massage, focusing on areas with enlarged pores. Start 2 to 3 times a week to let your skin get used to retinol, then increase the frequency if your skin tolerates it well. Always finish with a moisturizer, and don’t forget sunscreen the next morning.