Apply this serum in the evening on clean, dry skin, after your lotion/toner. Place a few drops over the entire face, avoiding the eye area, then massage until fully absorbed. Start 2 to 3 times a week to get your skin used to retinal, then gradually increase if your skin tolerates it well. Always finish with a good moisturizer, and in the morning, never skip sunscreen to boost the anti-spot and radiance effect.