MEDICUBE PDRN Pink Cica Soothing Toner — Lotion Réparatrice ADN Saumon

This first-step lotion concentrates six key active ingredients derived from Korean dermatological research.

Niacinamide — This form of vitamin B3 works on several fronts: it reduces pigmentation spots, strengthens the skin barrier, and regulates sebum production without drying out.

PDRN (Sodium DNA) — Short for Polydeoxyribonucleotide, this active ingredient extracted from salmon DNA has remarkable biocompatibility with human skin (~98% structural similarity). It consists of DNA fragments mainly extracted from trout or salmon sperm cells, which can be derived into Sodium DNA. It activates A2A adenosine receptors, thereby stimulating collagen production and accelerating tissue repair.

Centella Asiatica (Cica) — Double extract (leaf + whole plant) to maximize the supply of asiaticoside and madecassoside, two triterpenes that soothe redness and promote healing.

5-Peptide Complex — Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7 work synergistically to firm the dermal structure and smooth fine lines.

Sodium Hyaluronate — Sodium form of hyaluronic acid, capable of holding up to 1000 times its weight in water, for instant and lasting hydration.

Gluconolactone (PHA) — Next-generation polyhydroxy acid, it gently exfoliates without irritation, refines skin texture, and boosts natural radiance.

☀️ Morning routine

1. Cleanse your face with a gel or foam suitable for your skin type.
2. Pour a few drops of lotion into the palm of your hands or onto a reusable cotton pad.
3. Gently pat all over your face and neck to promote absorption.
4. Follow with your usual serum, then your moisturizer.
5. Finish with a sunscreen of at least SPF30 (PDRN and niacinamide require sun protection).

🌙 Evening routine

1. After double cleansing, apply the lotion using the same method (hands or cotton).
2. For intensive care: soak two cotton pads and leave them on sensitive or marked areas (cheeks, forehead) for 5 minutes.
3. Continue with your night actives (retinol, AHA/BHA if your skin tolerates them after 48 hours of adaptation).
4. Seal everything with a rich cream or a sleeping mask.

This toner is suitable for various skin types, each finding a targeted solution:

• Sensitive and reactive skin — The PDRN + cica duo soothes inflammation and strengthens the protective barrier weakened by external aggressors (pollution, air conditioning, stress).
• Dull skin with pigmentation marks — Clinically tested to improve the appearance of post-acne marks and hyperpigmentation in the deeper layers of the skin in just 2 weeks.
• Dehydrated skin lacking radiance — This lotion replenishes hydration across 10 layers deep for supple and radiant skin.
• Skin losing firmness (25 years and older) — Peptides and PDRN stimulate endogenous collagen synthesis, slowing early sagging.
• Combination to oily skin — Ultra-light watery texture that absorbs without a greasy film, while regulating sebum production via niacinamide.

Avoid if : known allergy to fish derivatives (although PDRN is highly purified and allergenic proteins are removed during the process).

The effects of this lotion follow a progressive timeline that you can observe step by step.

From the first applications : immediate sensation of freshness, soothing of redness and discomfort, quick absorption without stickiness. The skin regains its comfort and suppleness.

After 2 weeks of daily use : visible improvement of post-acne marks and hyperpigmentation in the deeper layers of the skin. The complexion becomes more even, dull areas fade, and natural radiance returns.

After 4 to 6 weeks : skin texture refines, dehydration fine lines diminish, firmness increases thanks to the combined action of peptides and PDRN on collagen production. The skin barrier is visibly strengthened, and the skin reacts less to environmental changes.

Continuously : maintaining optimal hydration across multiple dermal layers, preventing premature aging, and increasing resilience against daily aggressions.

What is the difference between this toner and MEDICUBE's PDRN Pink Peptide Toner?

The Pink Cica Soothing Toner focuses on soothing and evening out the complexion (PDRN + cica + niacinamide + 5 peptides + PHA), while the Pink Peptide Toner contains 10 peptides and targets skin elasticity and bounce more. If your priority is to calm irritation and reduce pigmentation marks, choose the Soothing. For maximum firmness boost, go for the Peptide.

Can I use it with retinol or AHA/BHA acids?

Yes, but wait 48 hours after the first application before introducing strong exfoliating actives. PDRN and cica enhance skin tolerance, but it’s best to proceed gradually. Always apply the lotion first, then your active, then your cream. Space out acid nights if you notice tightness.

How long does the 250ml bottle last with daily use?

Between 2.5 and 3 months if you use it morning and evening (3 to 4 drops per application are enough). It’s a generous size offering an excellent quantity/price ratio for such a sought-after active ingredient.

Why is the color naturally pink?

Its naturally pink-tinted formula is designed to fit perfectly into any skincare routine. This shade comes from cyanocobalamin (vitamin B12) present in the formula, not from an artificial dye. It does not alter your skin color upon application.

Can it be applied as a mask with soaked cotton pads?

For a more intensive treatment, soak a cotton pad with the lotion and apply it as a mask on the needed areas for a few minutes. This is ideal for targeting persistent redness areas (cheeks, around the nose) or stubborn pigmentation marks (forehead, temples).

Does PDRN really work topically, or are injections necessary?

PDRN is a large molecule and doesn’t penetrate the skin as well, so if you apply it topically, the effects are probably much milder. Injections (like Rejuran) remain more effective for spectacular anti-aging results, but topical PDRN is emerging as a trendy anti-aging active, generally well tolerated and offering good biocompatibility with human skin. Expect real but gradual benefits.

MEDICUBE offers solutions for sensitive and acne-prone skin through various product lines targeting skin concerns such as dryness, dull complexion, and pore care. All made in Korea, the brand's products ensure effectiveness at every step of your skincare routine.

The brand has established itself as a reference in the cosmeceutical segment — products that lie halfway between cosmetics and pharmaceuticals. The brand's best-sellers include the Red Capsule Cushion, Zero Pore Pad, Red Concealer, Red Foam Cleanser, and Red Erasing Cream..

The PDRN Pink Cica Soothing Toner is part of MEDICUBE's Pink line, which capitalizes on the global enthusiasm for PDRN — an active ingredient from Korean regenerative medicine, long reserved for dermatology clinics in Seoul, now accessible in our bathrooms. The brand has successfully translated this injectable technology into stable and effective topical formulas.

Discover the entire MEDICUBE range

Water / Aqua, Sodium Citrate, Citric Acid, Gluconolactone, Allantoin, Disodium EDTA, Xylitol, Niacinamide, Adenosine, 1,2-Hexanediol, Glycerin, Butylene Glycol, Polyglyceryl-10 Laurate, Polyglyceryl-4 Laurate, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Ethylhexylglycerin, Sodium DNA, Cyanocobalamin, Centella Asiatica Leaf Extract, Centella Asiatica Extract, Zea Mays (Corn) Leaf Extract, Sodium Hyaluronate, Glycine, Glutamic Acid, Arginine, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carica Papaya (Papaya) Fruit Extract, Pyrus Malus (Apple) Fruit Extract, Prunus Mume Fruit Extract

Some key active ingredients explained:

• Sodium DNA — INCI name for PDRN, the star regenerating active ingredient.
• Gluconolactone — A gentle exfoliating PHA (polyhydroxy acid), perfect for sensitive skin.
• Adenosine — An anti-wrinkle active recognized by the KFDA (Korean authority), stimulates collagen synthesis.
• Cyanocobalamin — Vitamin B12, an antioxidant that provides the product’s natural rosy tint.
• Allantoin — A soothing agent extracted from comfrey, repairs and softens.
• Xylitol — A plant-derived humectant that retains moisture.

Formula without artificial fragrance, essential oils, or drying alcohol. The light natural scent comes from botanical extracts (papaya, apple, plum).