Apply these ABIB PDRN Retinol eye patches on clean, dry skin, positioning them under each eye with the gel side against the skin. Leave on for 10 to 20 minutes to allow the retinol and PDRN to work on fine lines and brighten the eye contour, then gently remove and pat the excess serum until absorbed. Use preferably in the evening, 2 to 3 times a week, and then apply your eye cream or moisturizer.