REJURAN Triple Radiance Ampoule — c-PDRN 0.5% Anti-Âge

This ampoule combines active ingredients that are making waves in Korean dermatology clinics.

c-PDRN 0.5% (Hydrolyzed DNA): purified salmon DNA fragments, 97% identical to human DNA. This polynucleotide acts as a biostimulator: it binds to the adenosine receptors of your fibroblasts and triggers the neosynthesis of collagen and elastin. The result? Skin that repairs itself from within, without injections.

Niacinamide (active form of vitamin B3): inhibits the transfer of melanin to keratinocytes, gradually reducing pigmentation spots. Here, it works in synergy with botanical extracts for an even brightening effect without irritating the epidermis.

Adenosine : this anti-aging ingredient recognized by the Korean MFDS stimulates the production of type I and III collagen, which provide firmness and bounce. It smooths fine lines after 4 weeks of regular use.

Licorice Extract (Glycyrrhiza Glabra Root Extract) : its active fraction, glabridine, blocks tyrosinase (the key enzyme in melanogenesis). Studies show that 0.5% glabridine inhibits UV-induced pigmentation in guinea pigs — here, it works together with black mulberry and calendula to reveal an even complexion.

Sodium Hyaluronate + Panthenol : a moisturizing duo that captures water in the stratum corneum and strengthens the skin barrier. Panthenol (provitamin B5) also soothes reactive redness, ideal if you’ve just had a peel or laser treatment.

☀️ Morning routine

1. After the toner, place 3 to 4 drops in the palm and warm them for a few seconds between your hands.
2. Apply gently tapping all over the face, focusing on areas prone to spots (cheekbones, forehead).
3. Let absorb for 30 seconds, then follow with your moisturizer and SPF50+ sunscreen (mandatory, as niacinamide makes the skin photosensitive during the first weeks).

🌙 Evening routine

1. On perfectly cleansed and toned skin, apply 4 drops of the ampoule, smoothing from the center outward on the face.
2. Gently massage the contours of the face and neck to boost microcirculation.
3. If you use retinol or an acid (AHA/BHA), wait 10 minutes after the ampoule before applying them — c-PDRN has a neutral pH, so it does not interfere with the effectiveness of the following actives.
4. Seal with a nourishing cream to maximize the nighttime regenerating effect.

Frequency: Morning and evening, until the bottle is finished (about 1 month of daily use). For an intensive boost, you can double the dose in the evening for the first 10 days.

This ampoule is designed for several profiles:

• Mature skin seeking density : c-PDRN boosts collagen synthesis where traditional creams stall. Ideal from age 35.
• Tired or dull complexions : if your skin texture lacks clarity (pollution, stress, fatigue), niacinamide + botanical extracts revive radiance in just 2 weeks.
• Post-aesthetic treatment : after laser, peeling, or microneedling, c-PDRN speeds up healing and reduces inflammation. Usable from day 1 (if no open wounds).
• Fans of clinical K-beauty : if you want to replicate the “skin booster” effect at home without injections, this is the flagship product of that trend.
• Combination to oily skin : the fluid texture absorbs without a greasy film, unlike oil-based ampoules.

Avoid if:

• Known allergy to fish-derived products (c-PDRN is salmon-derived, even purified).
• Highly reactive skin in crisis (active eczema, severe rosacea): wait for remission phase, as some botanical extracts may sting.
• Pregnancy/breastfeeding: as a precaution, the use of marine biotechnology actives is not documented in these contexts — consult your dermatologist.

Triple action visible in 4 weeks:

From 7 days : the skin is better hydrated, the complexion looks fresher upon waking. Post-treatment redness (if you had a light peel) noticeably fades.

After 2 weeks : radiance stabilizes, small pigment spots begin to fade thanks to niacinamide and licorice. The skin texture becomes smoother to the touch.

After 4 weeks : expression lines (crow’s feet, frown lines) are visibly reduced, the facial contour appears reshaped. This is the cumulative effect of c-PDRN on neocollagenesis: your skin has literally rebuilt its foundation.

Prolonged use (8-12 weeks) : Korean clinical studies on 22 subjects show a significant improvement in skin elasticity and a 40% reduction in acne scars after 3 months of twice-daily application. The complexion becomes even, almost translucent — the famous sought-after “glass skin.”

Key point: c-PDRN is not a “flash” active ingredient like caffeine. It needs time to work at the cellular level. Patience pays off, we promise.

What is the difference between this Triple Radiance Ampoule and the REJURAN Turnover Ampoule?

The Turnover Ampoule (also with 0.5% c-PDRN) primarily targets overall cell regeneration and repair. The Triple Radiance Ampoule adds a concentrated brightening complex (niacinamide, black mulberry extracts, licorice, blueberry) to specifically improve skin tone evenness and radiance. If you mainly want to reduce spots and revive glow, this is the one for you.

Can I use it morning AND night?

Yes, it is even recommended to maximize the effect. In the morning, it prepares the skin and strengthens protection against free radicals (thanks to botanical antioxidants). At night, it boosts the nighttime regeneration driven by c-PDRN. Just make sure to apply SPF50+ in the morning, as niacinamide can temporarily increase sun sensitivity.

How long does a 30 ml bottle last?

About 1 month with twice-daily use (3-4 drops morning and night). If you use it only at night, it can last up to 6 weeks. Once opened, use it within 3 months to preserve the integrity of the c-PDRN.

Can I combine it with retinol or acids (AHA/BHA)?

Absolutely. c-PDRN has a neutral pH and does not interfere with the action of acids or retinol. Always apply the ampoule first (after toner), wait 10 minutes, then follow with your active treatment. c-PDRN even soothes potential retinol irritation thanks to its anti-inflammatory properties.

Is topical c-PDRN as effective as REJURAN injections in clinic?

No, intradermal injections deliver c-PDRN directly into the dermis, where fibroblasts are located, resulting in faster and more dramatic results (especially on deep scars). The topical version, with REJURAN’s patented DOT technology, penetrates up to the upper dermis layers using optimized polynucleotide fragments. It offers gradual benefits, ideal for maintenance or if you prefer to avoid injections.

Why use salmon DNA? Is it safe?

Salmon has DNA with a molecular structure (50-1500 kDa) that is 97% compatible with human DNA, allowing optimal recognition by our cell receptors. c-PDRN is extracted from wild salmon sperm, then purified through strict protocols to remove all proteins and pathogens. Clinical studies since the 1980s (initially in Italy for wound healing) confirm its safety and efficacy. REJURAN uses patented DOT (DNA Optimizing Technology) that further fragments and purifies the polynucleotides.

REJURAN emerged from a fortunate scientific accident: in 2012, a team of South Korean researchers from PharmaResearch Products (PRP)in Seoul was studying polymers for wound healing when they discovered that polynucleotides extracted from salmon DNA stimulated collagen production three times faster than standard treatments. In 2015, after filing 7 patents and conducting clinical trials on 80 patients showing a 42% faster healing of acne scars, REJURAN Healer was born — initially as an injectable treatment in clinics.

The success was immediate in South Korea, where medical aesthetics is a cutting-edge industry: by 2017, 85% of clinics in Seoul offered REJURAN injections. The brand then developed a “home care” cosmetic line with its proprietary technology DOT (DNA Optimizing Technology), which allows c-PDRN to penetrate the skin barrier without needles — a biotechnological feat validated by over 10 years of clinical research.

Today, REJURAN is distributed in more than 20 countries and embodies clinical K-beauty: scientifically proven, transparent formulas that focus on cellular regeneration rather than cosmetic camouflage. Their global ambassador, Kim Se-jeong, sums up their philosophy: “What changes the skin is not hope or expectation, but scientific truth.”

Discover the entire REJURAN range

Full INCI: Water, Butylene Glycol, Niacinamide, Morus Nigra Leaf Extract, Salix Alba (Willow) Bark Extract, 1,2-Hexanediol, Vaccinium Angustifolium (Blueberry) Fruit Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Calendula Officinalis Flower Extract, Yeast Extract, Hydrolyzed DNA (c-PDRN 0.5%), Glycereth-26, Glycerin, PEG-8, Polysorbate 20, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hyaluronate, Allantoin, Panthenol, Ethylhexylglycerin, Xanthan Gum, Adenosine, Fragrance, Hyaluronic Acid, Sodium Hydroxide.

Key active ingredients explained:

Hydrolyzed DNA (c-PDRN 0.5%) : the technological gem. These purified salmon DNA fragments (polynucleotides from 50 to 1500 kDa) activate the adenosine A2A receptors of your fibroblasts, triggering a regeneration cascade: neocollagenesis, neoangiogenesis (formation of new vessels to oxygenate the skin), inflammation reduction. This is the ingredient that revolutionized Korean aesthetic dermatology.

Niacinamide : vitamin B3 in its active form. Here, it plays a triple role — brightening (inhibits melanin transfer), soothing (regulates sebum production), and strengthening the skin barrier (stimulates ceramide synthesis).

Adenosine : anti-wrinkle active recognized by the Korean MFDS (equivalent to our ANSM). It acts as a cellular signal that stimulates the production of collagen I and III, responsible for firmness.

Brightening botanical complex : black mulberry (natural arbutin), licorice (anti-tyrosinase glabridin), cornflower (antioxidant), calendula (soothing). Together, they slow melanogenesis without irritation, unlike hydroquinone.

Sodium Hyaluronate + Hyaluronic Acid : two molecular weights of hyaluronic acid for deep (low molecular weight) and surface (high molecular weight) hydration. Immediate plumping effect.

Panthenol (provitamin B5) : humectant and barrier repairer. It reduces inflammation caused by other actives (perfect if you use retinol alongside).

Allantoin : gentle keratolytic agent that promotes the shedding of dead cells and improves penetration of other actives.

Formula without parabens, sulfates, dermatologically tested. Cruelty-free (the salmon is sourced from sustainable fisheries, the c-PDRN extracted from by-products that would otherwise be wasted).