Apply this JUMISO Niacinamide 20 serum on clean skin, right after toner. Place 2 to 3 drops in the palm of your hand, then gently pat it all over your face, avoiding the eye area. Use it preferably in the evening (or in the morning with good sun protection), 3 to 4 times a week at first, then increase the frequency if your skin tolerates it well. Always finish with a moisturizer to maximize radiance and reduce spots.