REJURAN Derma Healer — Ampoule PDRN Barrière Cutanée

This clinical ampoule concentrates reparative actives derived from South Korean dermatological research, developed in collaboration with DrJ Skin Clinic.

PDRx Complex (70,000 ppm) — Proprietary REJURAN complex combining polynucleotides and soothing botanical extracts. Clinically tested to reduce skin irritation by 77.6% and improve transepidermal water loss by 74%,it targets diffuse redness and post-treatment discomfort.

c-PDRN (5,000 ppm) — Fragmented polynucleotide derived from salmon DNA (Hydrolyzed DNA). These bioactive fragments stimulate adenosine receptors to activate tissue repair and boost collagen productionwithout the irritation associated with exfoliating acids.

Niacinamide (Vitamin B3) — Multifunctional active that evens skin tone, regulates sebum production, and strengthens the barrier function. Works synergistically with polynucleotides to improve skin tolerance.

Barrier Triad: Ceramide NP + Cholesterol + Fatty Acids — Mimics the natural lipid structure of the epidermis. This biomimetic combination locks in hydration while preventing environmental dehydration.

Sodium Hyaluronate — Sodium form of hyaluronic acid, capable of absorbing up to 1000 times its weight in water. Maintains the surface water film for an immediate plumping effect.

Adenosine — Cellular energy molecule recognized by the Korean MFDS for its anti-wrinkle action. Stimulates collagen synthesis and improves skin firmness over time.

☀️ Morning routine

1. Cleanse and tone your face
2. Place 3-4 drops of the ampoule in your palm
3. Warm it between your hands, then gently press onto your face and neck
4. Tap lightly until fully absorbed — the texture melts in without leaving a sticky film
5. Follow with your moisturizer, then your sunscreen

🌙 Evening routine

1. After your double cleansing and toner
2. Apply the ampoule on slightly damp skin to boost absorption
3. If you use retinol or an acid, wait for the ampoule to absorb (2-3 min) before applying your treatment — the c-PDRN protects the barrier during active protocols
4. Seal with a rich cream or sleeping mask to maximize overnight repair

💡 Intensive use : As a treatment boost, the ampoule delivers lasting hydration for 48 hours after a single applicationOn very dry days or after exposure (sun, air conditioning, long-haul flight), double the dose morning and evening for 3-5 days.

Recommended profiles:

• Reactive and dehydrated skin — If you spend your time soothing redness and tightness, the PDRx + c-PDRN duo rebalances the skin microbiome and rebuilds the damaged lipid barrier
• Post-dermatological treatment — Ideal after microneedling, laser, or peeling : polynucleotides accelerate healing and reduce residual inflammation
• Skin tired from urban pollution — Ceramides + cholesterol form an anti-aggression shield that limits the penetration of fine particles
• Retinol/acids transition — Want to introduce exfoliating actives without compromising your barrier? This ampoule creates a protective cushion that minimizes sensitization
• Anti-aging prevention from age 25 — In South Korea, the philosophy is preventive: young adults use PDRN to maintain skin density before the first signs appear

⚠️ Avoid if:

• Allergy to seafood (c-PDRN is derived from salmon DNA — although purified, caution in case of severe allergy)
• Very oily skin seeking an ultra-light texture: prefer a pure aqueous serum

From the first application : Immediate cooling effect with a skin temperature drop of 6°C, comfort sensation restored, redness visibly reduced.

After 2 weeks of daily use : Skin texture refines, flaky areas disappear. Hydration is maintained longer throughout the day — you will space out mist touch-ups.

After 4 weeks : 111% improvement in immediate hydration capacity. The strengthened barrier better resists climatic variations. Post-inflammatory marks begin to fade thanks to niacinamide.

After 6-8 weeks : Skin gains resilience — less reactivity to cosmetics, better tolerance to active ingredients. Adenosine and c-PDRN gradually stimulate collagen production for a visible rebound effect.

Realistic timeline : This is not an instant dramatic transformation, but a methodical reconstruction of skin health. South Korean dermatologists recommend a minimum of 3 months to observe complete barrier regeneration.

What is the difference between PDRx and c-PDRN in this formula?

PDRx is a proprietary REJURAN/DrJ Skin Clinic complex known for its soothing and moisturizing properties, while c-PDRN is specifically dedicated to skin condition care.Together, they work on two fronts: calming surface inflammation (PDRx) and stimulating deep regeneration (c-PDRN).

Can I use it with my retinol or AHA/BHA acids?

Absolutely, it’s even recommended. First apply the REJURAN ampoule, let it absorb for 2-3 minutes, then apply your exfoliating active. PDRN helps repair tissues without the irritation associated with traditional acidsmaking it an excellent protective buffer.

How long does the 30ml bottle last?

With daily use morning and evening (3-4 drops per application), expect about 6-8 weeks. If you use it only at night or as a targeted treatment, the bottle can last 2-3 months.

Is the grapefruit scent strong?

The formula contains grapefruit essential oil (Citrus Paradisi Peel Oil) in very low concentration. The scent is subtle, slightly citrusy, and fades quickly after application. If you are sensitive to essential oils, do a patch test on your forearm 24 hours before.

Can it be used around the eyes?

Yes, but sparingly. REJURAN makes a specific version for the eye contour (Rejuran I), but this facial ampoule remains safe on the periorbital area if applied with gentle tapping, without pulling the skin. Avoid direct contact with mucous membranes.

Difference from REJURAN Healer injections in clinic?

Intradermal injections deliver polynucleotides directly into the dermis, bypassing the skin barrier for immediate cellular interaction and more dramatic results on deep scars.This topical ampoule offers a gentler, gradual approach, ideal for daily maintenance and prevention, with no needles or downtime.

REJURAN was officially launched in South Korea in the mid-2010s by a biomedical company specializing in DNA-based therapies. The product was developed by PharmaResearch Products, a South Korean biotechnology company that obtained approval from the MFDS (Ministry of Food and Drug Safety) several years before any commercialization elsewhere in the world.

The development of REJURAN is based on decades of medical research on DNA-based regenerative therapies. In the 1990s and early 2000s, scientists began studying salmon DNA as a potential therapeutic agent for skin healing, wound care, and tissue regeneration.

Today, REJURAN is present in more than 20 countries and holds about 60% of the polynucleotide skincare market in Asia. The brand reached a milestone in March 2026 with its arrival at Sephora in the United States, making its c-PDRN® technology accessible to the Western public.

What sets REJURAN apart is its biomimetic approach: rather than masking imperfections, the formulas literally teach the skin to behave more youthfully by stimulating its own repair mechanisms at the cellular level.

Discover the entire REJURAN range

Complete INCI list:

Water, Rubus Fruticosus (Blackberry) Leaf Extract, Butylene Glycol, Glycerin, Calendula Officinalis Extract, Dipropylene Glycol, Aloe Barbadensis Leaf Juice, Morus Nigra Fruit Extract, Sodium Hyaluronate, Niacinamide, Cucumis Sativus (Cucumber) Fruit Extract, Avena Sativa (Oat) Kernel Extract, Hydrolyzed DNA, Xanthan Gum, Citrus Paradisi (Grapefruit) Peel Oil, 1,2-Hexanediol, Laminaria Ochroleuca Extract, Ethylhexylglycerin, Adenosine, Squalane, Caprylic/Capric Triglyceride, Ceramide NP, Hydrogenated Lecithin, Pentylene Glycol, Palmitic Acid, Cholesterol, Oleic Acid, Inulin Lauryl Carbamate

Key active ingredients analysis:

Hydrolyzed DNA — This is c-PDRN. Fragmented into low molecular weight polynucleotides to facilitate skin penetration and activation of cellular receptors.

Soothing botanical extracts — Blackberry (Rubus Fruticosus), Calendula, Aloe Vera, Cucumber: an anti-inflammatory cocktail that supports the soothing action of the PDRx Complex.

Colloidal Oatmeal (Avena Sativa Kernel Extract) — An emollient and soothing agent recognized for atopic skin. Enhances the formula’s tolerance on hypersensitive epidermis.

Golden Algae (Laminaria Ochroleuca Extract) — A marine antioxidant that protects against UV oxidative stress and pollution.

Clean formula : Free from parabens, sulfates, and animal cruelty. Suitable for minimalist skincare routines and the most reactive skin types.