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Our team advises you to apply the ANUA Retinol 0.3 Niacin Renewing Serum in the evening on clean, dry skin. Place 2 to 3 drops on the face and neck, then gently massage until fully absorbed. Start by using it 2 to 3 times a week, then gradually increase the frequency according to your skin's tolerance. Remember to apply a moisturizer after the serum and to use sun protection the next morning.